Top 100 in Neuroscience

This collection highlights our most downloaded* neuroscience papers published in 2021. Featuring authors from around the world, these papers showcase valuable research from an international community.

*Data obtained from SN Inights, which is based on Digital Science's Dimensions.

1-25

Musical components important for the Mozart K448 effect in epilepsy

• Robert J. Quon
• Michael A. Casey
• Barbara C. Jobst

Brain structure changes associated with sexual orientation

• Mikhail Votinov
• Katharina S. Goerlich
• Ute Habel

Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain

• Fabien Dachet
• James B. Brown
• Jeffrey A. Loeb

Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition

• Lisa Mosconi
• Valentina Berti
• Roberta Diaz Brinton

Multimodal deep learning models for early detection of Alzheimer’s disease stage

• Janani Venugopalan
• Li Tong
• May D. Wang

Brain tumor segmentation based on deep learning and an attention mechanism using MRI multi-modalities brain images

• Ramin Ranjbarzadeh
• Abbas Bagherian Kasgari
• Malika Bendechache

Splitting sleep between the night and a daytime nap reduces homeostatic sleep pressure and enhances long-term memory

• James N. Cousins
• Ruth L. F. Leong
• Michael W. L. Chee

Listening to speech with a guinea pig-to-human brain-to-brain interface

• Claus-Peter Richter
• Petrina La Faire
• Alan G. Micco

Benefit of human moderate running boosting mood and executive function coinciding with bilateral prefrontal activation

• Chorphaka Damrongthai
• Ryuta Kuwamizu
• Hideaki Soya

Enhanced activations in syntax-related regions for multilinguals while acquiring a new language

• Keita Umejima
• Suzanne Flynn
• Kuniyoshi L. Sakai

Brain-inspired spiking neural networks for decoding and understanding muscle activity and kinematics from electroencephalography signals during hand movements

• Kaushalya Kumarasinghe
• Nikola Kasabov
• Denise Taylor

Longitudinal effects of meditation on brain resting-state functional connectivity

• Zongpai Zhang
• Wen-Ming Luh
• Weiying Dai

Evidence of a new hidden neural network into deep fasciae

• Caterina Fede
• Lucia Petrelli
• Carla Stecco

Cross-sex hormone treatment and own-body perception: behavioral and brain connectivity profiles

• Behzad S. Khorashad
• Amirhossein Manzouri
• Ivanka Savic

A directional 3D neurite outgrowth model for studying motor axon biology and disease

• Xandor M. Spijkers
• Svetlana Pasteuning-Vuhman
• R. Jeroen Pasterkamp

The role of dorsolateral and ventromedial prefrontal cortex in the processing of emotional dimensions

• Vahid Nejati
• Reyhaneh Majdi
• Michael A. Nitsche

How neurons exploit fractal geometry to optimize their network connectivity

• Julian H. Smith
• Conor Rowland
• R. P. Taylor

Defining early changes in Alzheimer’s disease from RNA sequencing of brain regions differentially affected by pathology

• Boris Guennewig
• Julia Lim
• Greg T. Sutherland

Narcissistic personality traits and prefrontal brain structure

• Igor Nenadić
• Carsten Lorenz
• Christian Gaser

EEG-based diagnostics of the auditory system using cochlear implant electrodes as sensors

• Ben Somers
• Christopher J. Long
• Tom Francart

Investigating real-life emotions in romantic couples: a mobile EEG study

• Julian Packheiser
• Gesa Berretz
• Sebastian Ocklenburg

Sex-dependent alterations in behavior, drug responses and dopamine transporter expression in heterozygous DAT-Cre mice

• Kauê Machado Costa
• Daniela Schenkel
• Jochen Roeper

Functional network connectivity during Jazz improvisation

• Victor M. Vergara
• Martin Norgaard
• Vince D. Calhoun

Buspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice

• Jeon-Kyung Kim
• Sang-Kap Han
• Dong-Hyun Kim

Human cerebral organoids as a therapeutic drug screening model for Creutzfeldt–Jakob disease

• Bradley R. Groveman
• Natalia C. Ferreira
• Cathryn L. Haigh

26-50

Thioflavin-positive tau aggregates complicating quantification of amyloid plaques in the brain of 5XFAD transgenic mouse model

• Jisu Shin
• Sohui Park
• YoungSoo Kim

Ambulatory seizure forecasting with a wrist-worn device using long-short term memory deep learning

• Mona Nasseri
• Tal Pal Attia
• Benjamin H. Brinkmann

Post-traumatic seizures and antiepileptic therapy as predictors of the functional outcome in patients with traumatic brain injury

• Valeria Pingue
• Chiara Mele
• Antonio Nardone

Human α-synuclein overexpression in a mouse model of Parkinson’s disease leads to vascular pathology, blood brain barrier leakage and pericyte activation

• Osama Elabi
• Abderahim Gaceb
• Gesine Paul

Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysis

• Natalia Roberto
• Maria J. Portella
• Sergi Valero

Comparative neuroanatomy of the lumbosacral spinal cord of the rat, cat, pig, monkey, and human

• Amirali Toossi
• Bradley Bergin
• Vivian K. Mushahwar

A personalized and evolutionary algorithm for interpretable EEG epilepsy seizure prediction

• Mauro. F. Pinto
• Adriana Leal
• César A. Teixeira

The effects of positive or negative self-talk on the alteration of brain functional connectivity by performing cognitive tasks

• Junhyung Kim
• Joon Hee Kwon
• Jae-Jin Kim

Deep learning-Based 3D inpainting of brain MR images

• Seung Kwan Kang
• Seong A. Shin
• Jae Sung Lee

Both high fat and high carbohydrate diets impair vagus nerve signaling of satiety

• Hailley Loper
• Monique Leinen
• Matthew A. Schiefer

PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons

• Sarah J. Brown
• Ibrahim Boussaad
• Oliver Bandmann

Altered spontaneous activity in the frontal gyrus in dry eye: a resting-state functional MRI study

• Kang Yu
• Yu Guo
• Yi Shao

Online and offline effects of transcranial alternating current stimulation of the primary motor cortex

• Ivan Pozdniakov
• Alicia Nunez Vorobiova
• Matteo Feurra

Cell type-specific changes in transcriptomic profiles of endothelial cells, iPSC-derived neurons and astrocytes cultured on microfluidic chips

• H. H. T. Middelkamp
• A. H. A. Verboven
• A. D. van der Meer

Brain MRI in SARS-CoV-2 pneumonia patients with newly developed neurological manifestations suggestive of brain involvement

• Batil Alonazi
• Ahmed M. Farghaly
• Mustafa Z. Mahmoud

Diazepam causes sedative rather than anxiolytic effects in C57BL/6J mice

• Marina Pádua-Reis
• Diana Aline Nôga
• Martina Blunder

Photons detected in the active nerve by photographic technique

• Andrea Zangari
• Davide Micheli
• Maria Emiliana Caristo

Cannabidiol induces autophagy via ERK1/2 activation in neural cells

• Talita A. M. Vrechi
• Anderson H. F. F. Leão
• Gustavo J. S. Pereira

Deep learning-based pupil model predicts time and spectral dependent light responses

• Babak Zandi
• Tran Quoc Khanh

ATP signaling in the integrative neural center of Aplysia californica

• János Györi
• Andrea B. Kohn
• Leonid L. Moroz

EEG signals respond differently to idea generation, idea evolution and evaluation in a loosely controlled creativity experiment

• Wenjun Jia
• Yong Zeng

Cognitive and MRI trajectories for prediction of Alzheimer’s disease

• Samaneh A. Mofrad
• Astri J. Lundervold
• Alexander S. Lundervold

Characterization of mitochondrial health from human peripheral blood mononuclear cells to cerebral organoids derived from induced pluripotent stem cells

• Angela Duong
• Alesya Evstratova
• Ana C. Andreazza

Astrocytic expression of the Alzheimer’s disease risk allele, ApoEε4, potentiates neuronal tau pathology in multiple preclinical models

• Angela Marie Jablonski
• Lee Warren
• Bhavya Voleti

Effects of the sigma-1 receptor agonist blarcamesine in a murine model of fragile X syndrome: neurobehavioral phenotypes and receptor occupancy

• Samantha T. Reyes
• Robert M. J. Deacon
• Frederick T. Chin

51-75

Magnetic domains oscillation in the brain with neurodegenerative disease

• Gunther Kletetschka
• Robert Bazala
• Eva Svecova

Right frontal anxiolytic-sensitive EEG ‘theta’ rhythm in the stop-signal task is a theory-based anxiety disorder biomarker

• Shabah M. Shadli
• Lynne C. Ando
• Neil McNaughton

Role of miRNAs shuttled by mesenchymal stem cell-derived small extracellular vesicles in modulating neuroinflammation

• Debora Giunti
• Chiara Marini
• Antonio Uccelli

Position sensitive measurement of trace lithium in the brain with NIK (neutron-induced coincidence method) in suicide

• J. Schoepfer
• R. Gernhäuser
• M. Graw

Major oscillations in spontaneous home-cage activity in C57BL/6 mice housed under constant conditions

• Karin Pernold
• Eric Rullman
• Brun Ulfhake

Involvement of the dopaminergic system in the reward-related behavior of pregabalin

• Yusuf S. Althobaiti
• Farooq M. Almutairi
• Zahoor A. Shah

A high-density electroencephalography study reveals abnormal sleep homeostasis in patients with rapid eye movement sleep behavior disorder

• Amandine Valomon
• Brady A. Riedner
• Melanie Boly

MEG signatures of long-term effects of agreement and disagreement with the majority

• A. Gorin
• V. Klucharev
• A. Shestakova

Stroke prediction in patients presenting with isolated dizziness in the emergency department

• June-sung Kim
• Hong Jun Bae
• Won Young Kim

Age-dependent and region-specific alteration of parvalbumin neurons, perineuronal nets and microglia in the mouse prefrontal cortex and hippocampus following obesogenic diet consumption

• Amy C. Reichelt
• Claire A. Lemieux
• Lisa M. Saksida

Recording site placement on planar silicon-based probes affects signal quality in acute neuronal recordings

• Richárd Fiáth
• Domokos Meszéna
• István Ulbert

Amplification of potential thermogenetic mechanisms in cetacean brains compared to artiodactyl brains

• Paul R. Manger
• Nina Patzke
• Kjell Fuxe

Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth

• Marion I. van den Heuvel
• Jasmine L. Hect
• Moriah E. Thomason

An anomaly detection approach to identify chronic brain infarcts on MRI

• Kees M. van Hespen
• Jaco J. M. Zwanenburg
• Hugo J. Kuijf

The neurodynamic treatment induces biological changes in sensory and motor neurons in vitro

• Giacomo Carta
• Giovanna Gambarotta
• Federica Fregnan

Optimal flickering light stimulation for entraining gamma waves in the human brain

• Kanghee Lee
• Yeseung Park
• Ki Woong Kim

Two-photon GCaMP6f imaging of infrared neural stimulation evoked calcium signals in mouse cortical neurons in vivo

• Attila Kaszas
• Gergely Szalay
• David Moreau

The Aβ(1–38) peptide is a negative regulator of the Aβ(1–42) peptide implicated in Alzheimer disease progression

• Maa O. Quartey
• Jennifer N. K. Nyarko
• Darrell D. Mousseau

Drinking coffee enhances neurocognitive function by reorganizing brain functional connectivity

• Hayom Kim
• Sung Hoon Kang
• Jung Bin Kim

The impact of multisensory integration and perceptual load in virtual reality settings on performance, workload and presence

• Matteo Marucci
• Gianluca Di Flumeri
• Pietro Aricò

CuATSM improves motor function and extends survival but is not tolerated at a high dose in SOD1 G93A mice with a C57BL/6 background

• Jeremy S. Lum
• Mikayla L. Brown
• Justin J. Yerbury

Underlying neurological mechanisms associated with symptomatic convergence insufficiency

• Tara L. Alvarez
• Mitchell Scheiman
• Bharat B. Biswal

Paternal exposure to a common pharmaceutical (Ritalin) has transgenerational effects on the behaviour of Trinidadian guppies

• Alex R. De Serrano
• Kimberly A. Hughes
• F. Helen Rodd

Behavioral arrest and a characteristic slow waveform are hallmark responses to selective 5-HT_2A receptor activation

• April Contreras
• Matthew Khumnark
• Dustin J. Hines

Focused ultrasound mediated blood–brain barrier opening is safe and feasible in a murine pontine glioma model

• Zachary K. Englander
• Hong-Jian Wei
• Cheng-Chia Wu

76-100

Basmisanil, a highly selective GABA_A-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man

• Joerg F. Hipp
• Frederic Knoflach
• Maria-Clemencia Hernandez

Spatial memory deficiency early in 6xTg Alzheimer’s disease mouse model

• Shinwoo Kang
• Jinho Kim
• Keun-A Chang

The gut microbiome is associated with brain structure and function in schizophrenia

• Shijia Li
• Jie Song
• Kai Wu

Static and dynamic functional connectivity supports the configuration of brain networks associated with creative cognition

• Abhishek Uday Patil
• Sejal Ghate
• Chih-Mao Huang

Digital signatures for early traumatic brain injury outcome prediction in the intensive care unit

• Anil K. Palepu
• Aditya Murali
• Robert D. Stevens

LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1

• Ramona M. Rodriguiz
• Vineet Nadkarni
• William C. Wetsel

Modified wavelet analysis of ECoG-pattern as promising tool for detection of the blood–brain barrier leakage

• Anastasiya Runnova
• Maksim Zhuravlev
• Jurgen Kurths

Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization

• Hiromu Monai
• Shinnosuke Koketsu
• Hajime Hirase

An atlas for human brain myelin content throughout the adult life span

• Adam V. Dvorak
• Taylor Swift-LaPointe
• Shannon H. Kolind

Immediate and after effects of transcranial direct-current stimulation in the mouse primary somatosensory cortex

• Carlos A. Sánchez-León
• Isabel Cordones
• Javier Márquez-Ruiz

Human brain dynamics in active spatial navigation

• Tien-Thong Nguyen Do
• Chin-Teng Lin
• Klaus Gramann

Reading without phonology: ERP evidence from skilled deaf readers of Spanish

• Brendan Costello
• Sendy Caffarra
• Manuel Carreiras

Alterations in reward network functional connectivity are associated with increased food addiction in obese individuals

• Soumya Ravichandran
• Ravi R. Bhatt
• Arpana Gupta

Disease progression modelling from preclinical Alzheimer’s disease (AD) to AD dementia

• Soo Hyun Cho
• Sookyoung Woo
• Sang Won Seo

The structure dilemma in biological and artificial neural networks

• Thomas Pircher
• Bianca Pircher
• Andreas Feigenspan

Voluntary intake of psychoactive substances is regulated by the dopamine receptor Dop1R1 in Drosophila

• Mai Kanno
• Shun Hiramatsu
• Toshiharu Ichinose

The contribution of platelets to peripheral BDNF elevation in children with autism spectrum disorder

• Cristan A. Farmer
• Audrey E. Thurm
• Joan C. Han

Dopamine-loaded nanoparticle systems circumvent the blood–brain barrier restoring motor function in mouse model for Parkinson’s Disease

• Victoria Monge-Fuentes
• Andréia Biolchi Mayer
• Márcia Renata Mortari

NK1 antagonists attenuate tau phosphorylation after blast and repeated concussive injury

• Frances Corrigan
• Ibolja Cernak
• Robert Vink

Nicotine suppresses Parkinson’s disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels

• Angel Carvajal-Oliveros
• Carmen Domínguez-Baleón
• Enrique Reynaud

Free-water diffusion tensor imaging improves the accuracy and sensitivity of white matter analysis in Alzheimer’s disease

• Maurizio Bergamino
• Ryan R. Walsh
• Ashley M. Stokes

A functional spiking neuronal network for tactile sensing pathway to process edge orientation

• Adel Parvizi-Fard
• Mahmood Amiri
• Nitish V. Thakor

The difficulty to model Huntington’s disease in vitro using striatal medium spiny neurons differentiated from human induced pluripotent stem cells

• Kim Le Cann
• Alec Foerster
• Angelika Lampert

Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation

• Daniel Gomes de Almeida-Filho
• Bruna Del Vechio Koike
• Claudio Marcos Queiroz

Machine learning-based classification of mitochondrial morphology in primary neurons and brain

• Garrett M. Fogo
• Anthony R. Anzell
• Thomas H. Sanderson